Anticancer potential of NO-Donor Oxadiazole in malignant pleural mesothelioma – The Babak Lab
The Babak Lab shared a post on LinkedIn about a paper by Irina Stebletsova et al. published in Pharmaceutics:
“New Research Paper from The Babak Lab!
We are thrilled to announce the publication of our latest research paper, ‘Exploring the Anticancer Potential of NO-Donor Oxadiazole Assemblies Against Malignant Pleural Mesothelioma,’ in Pharmaceutics!
This work represents a significant advancement in the fight against malignant pleural mesothelioma (MPM), a rare and aggressive cancer linked to asbestos exposure.
Our key findings highlight:
- With our collaborators, we developed a novel class of nitric oxide (NO)-donor compounds by combining 1,2,5-oxadiazole 2-oxides (furoxans) and 1,2,4-oxadiazoles.
- These compounds demonstrated exceptional NO-releasing properties, outperforming existing NO donors by 1.5–3 times.
- In preclinical studies, the compounds showed high cytotoxicity against MPM cell lines in the low micromolar range, with greater selectivity for cancer cells compared to the standard-of-care drug cisplatin.
- The most potent compounds, 2d and 2k, exhibited IC50 values as low as 0.87 μM, making them promising candidates for further development.
Why This Matters:
MPM is a devastating disease with a 5-year survival rate of less than 5%. Current treatments are limited, and there is an urgent need for innovative therapeutic strategies. By leveraging the cytotoxic effects of NO on cancer cells, our research opens new avenues for targeted cancer therapy.
Congratulations to Egor Matnurov and Maria (Masha) Babak on this achievement!
We’d love to hear your thoughts and feedback! Let’s keep the conversation going in the comments below.”
Authors: Irina Stebletsova, Alexander Larin, Egor Matnurov, Ivan Ananyev, Maria Babak and Leonid Fershtat.
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