Fabio Ynoe Moraes, Associate Professor at Queen’s University, shared on LinkedIn:
“Very happy to see our new editorial published in the Journal of Clinical Oncology (JCO).
The clinical question is simple, but important: When the brain progresses but extracranial disease remains controlled, does the entire systemic strategy need to change?
Perhaps not. The emerging data suggest a different way of thinking about brain-only progression in extensive-stage SCLC: isolated CNS progression may represent sanctuary-site failure rather than global systemic treatment failure.
In selected patients, treating the brain with radiotherapy while preserving an otherwise effective systemic backbone may therefore be a reasonable strategy.
Our key message:
Treat the sanctuary. Preserve what is still working. Of course, retrospective evidence is not enough to settle the question. Prospective studies are needed, particularly as new systemic agents with greater intracranial activity enter the SCLC landscape.
Congratulations to Yuchen Li and Lilian Faroni – a pleasure working together on this clinically relevant discussion.”
Title: Brain-Only Progression After First-Line Therapy in Extensive-Stage Small Cell Lung Cancer: Treat the Sanctuary, Preserve the Backbone
Authors: Yuchen Li, Lilian Faroni and Fabio Ynoe Moraes
Read the full article.
