WRAD complex’s impact on epigenetic regulation and immunoediting in PDAC by Francesca Citron

Wafik S. El-Deiry shared a post on X:

” Francesca Citron from MD Anderson Cancer Center speaks about WRAD complex, its interaction with the replisome, its impact on epigenetic regulation and immunoediting in PDAC.”

DPY30 regulates immunoediting by suppressing uncoordinated DNA replication in pancreatic cancer.

Authors: Francesca Citron; Luigi Perelli; Chiara Balestrieri; Luca Cecchetto; Yanshuo Chu; I-Lin Ho; Li Zhang; Er-Yen Yen; Luis Castillo Montanez; Rutvi Shah; Sergio Attanasio; Sanjana Srinivasan; Charles Dyke; Ko-Chien Chen; Shan Jiang; Jing Pan; Sisi Gao; Huamin Wang; Wantong Yao; Linghua Wang; Mauro Di Pilato; Giannicola Genovese; Andrea Viale; Giulio Draetta.

Source: Wafik S. El-Deiry/X

Wafik S. El-Deiry, MD, PhD, FACP, FRSM, is the Associate Dean for Oncologic Sciences at the Warren Alpert Medical School and Director of the Legorreta Cancer Center at Brown University and Director of the Joint Program in Cancer Biology at Brown University and affiliated hospitals. He is the Editor in Chief at Oncotarget.

Dr. El-Deiry discovered p21(WAF1) as a p53 target gene, cell cycle inhibitor, and tumor suppressor that explained the mammalian cell stress response. Dr. El-Deiry’s research is focused on mechanisms of therapy resistance with major efforts in drug discovery and development.