The SIOP 2025 Congress – the 57th Annual Meeting of the International Society of Paediatric Oncology – took place in Amsterdam, the Netherlands, from October 20 to 23, bringing together the global childhood cancer community to advance outcomes across every stage of paediatric oncology care. Hosted at RAI Amsterdam, the congress reaffirmed its role as a premier forum for precision medicine, multidisciplinary collaboration, and real-world implementation in paediatric cancer.
This year’s scientific program spanned solid tumours and haematologic malignancies, with sessions highlighting progress in molecular diagnostics, data sharing to inform policy and practice, and translational research that is reshaping risk stratification and therapeutic decision-making. Discussions spotlighted biomarker-driven approaches, the integration of systemic and local therapies, and strategies to accelerate equitable access to innovation worldwide.
With four days of cutting-edge presentations, expert debates, and networking, SIOP 2025 emphasized clinically meaningful insights with direct relevance to patient care – while also strengthening global collaboration through initiatives and assemblies tied to the wider paediatric oncology ecosystem.
Firmly established as a cornerstone of the oncology calendar, SIOP 2025 once again demonstrated how coordinated science, policy, and practice can accelerate a world where no child should die of cancer.
Here are 12 key highlights from SIOP 2025.
“The My SIOP Photo Contest is officially open!
Show us your best moments from the congress, and you could win a free registration to SIOP 2026 in San Antonio, Texas!
Capture, share, and be part of the fun!”
“Bridging Communication in Paediatric Oncology – ‘Speak My Language‘ at SIOP 2025
Prof. Carmelo Rizzari opened the ‘Speak My Language’ session with an inspiring welcome, whose words reminded us of the importance of understanding, empathy, and collaboration across cultures and languages in paediatric oncology care.
Prof. Rizzari’s introduction set the tone for a meaningful discussion on how language can both empower families and strengthen global collaboration in childhood cancer treatment.
Looking forward to hearing from the outstanding speakers part of this vital conversation at SIOP2025 – together, we continue to make strides toward more inclusive, compassionate care for every child, everywhere.”
Alejandra Mendez, Vice President at Childhood Cancer International:
“I am happy and proud to be in Amsterdam, at the Childhood Cancer International (CCI) annual conference.
Collaboration is the key to success: Yesterday, we held a collaborative meeting between the International Society of Paediatric Oncology – SIOP and CCI board members.
Together we can save more children’s lives!”
Hedley Lewis, CEO at CHOC Childhood Cancer Foundation SA:
“Collaborative meeting between the Childhood Cancer International Board and the International Society of Pediatric Oncology Board in Amsterdam.
Collaboration is the cornerstone of supporting patients and families facing childhood cancer.
A united front between Childhood Cancer International and the International Society of Paediatric Oncology – SIOP is essential to advancing treatment, research, and care. Together, we’re making a difference – one family at a time.”
“Don’t miss our session TODAY from SIOPcongress at 12 PM!
‘Speak My Language: Rethinking Patient-Centered Communication in Childhood Cancer‘ features World Child Cancer USA board chair, Dana Bryson, as host of this panel, including clinicians, parents, influencers, and psychosocial experts who are reshaping how we talk to patients – not just about them.
Guillermo Chantada, President of the International Society of Paediatric Oncology (SIOP) and Head of Outreach Program at Pediatric Cancer Center Barcelona:
“The SIOP2025 congress in Amsterdam is starting now. Record high number of everything, especially quality and networking, and my last as President.”
“ACT organizations are featured on TWO panels today at SIOP Congress!
‘Speak My Language: Rethinking Patient-Centered Communication in Childhood Cancer‘ is hosted by World Child Cancer USA’s Dana Bryson in a wide-ranging panel of influencers and experts on how to best communicate with patients.
In the evening, Scott Howard from Resonance speaks at ‘Rewriting the Rules of Pediatric Acute Lymphoblastic Leukemia Treatment.’ Learn how an evidence-based model is reshaping pediatric ALL treatment globally – and what it will take to adopt it in your setting.”
Uta Dirksen, SIOPE President and Acting Director of Pediatrics III at the University of Duisburg-Essen:
“Great to see the entire international Community.”
Arnaud Lallouette, Executive Vice President Global Medical and Patient Affairs at Servier:
“It’s like being in a nuclear reactor, where all molecules together create a powerful dynamic!
As one of the participants said, this perfectly captures the spirit of the ACT for Children meetings, which I attended as an inaugural side event of SIOP Europe, the European Society for Paediatric Oncology (SIOPE) 2025.
In just one year, the initiative has evolved remarkably, bringing together knowledge, data, and above all, the dedication of passionate partners from around the world, all united by a single purpose: improving outcomes for children with cancer in low- and middle-income countries.
With participants from diverse organizations, the meetings were filled with open discussion, collaborative spirit, and shared inspiration. The progress achieved so far is tangible. Access to education and access to care, enough to optimize the treatment of about 2,000 children across Guatemala, El Salvador, Honduras, Indonesia, and Armenia.
The projects presented by participants go far beyond drug access, reflecting a holistic, hospital-focused approach to ensure relevant access to quality medicines, best-in-class clinical management, and comprehensive patient and family support.
Together, we’re building a model of care and shaping a brighter future for children with cancer worldwide.
Venkatraman Radhakrishnan, Associate Professor of Medical and Pediatric Oncology at Chennai Cancer Institute:
“Therapeutic drug monitoring in BMT. So many conditioning regimens.
No standard of care.
A Centre in the UK decided to have a single regimen for all transplants. Fludarabine Anti-thymocyte globulin and busulphan FLuBuATG and did TDM.”
“Surveillance improves outcomes in Li Fraummeni syndrome and Replication Repair Deficit syndromes. These cancers are sensitive to immunotherapy.”
“Sonic Hedge Hog pathway inhibitors lead to premature growth plate fusion. Similar FGFR inhibitors lead to slipped femoral epiphysis. Targeted therapy toxicity in children can be different from adults.”
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