Sanam Loghavi, Associate Professor of Pathology at MD Anderson Cancer Center, Medical Director of ECOG-ACRIN Leukemia Bank and Editor in Chief of Image Bank at the American Society of Hematology, shared on X:
“Excited and proud to share our special issue on Leukemia that L. Jeffrey Medeiros I put together for Human Pathology.
We brought together incredible experts to write about the latest in the field. 14 articles, each one hemepath GOLD!
Title: Introduction to special issue on leukemia
Authors: Sanam Loghavi and L. Jeffrey Medeiros
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First up, a fantastic review B-ALL with a focus on molecular classification by Roberta Azevedo and Nicholas Short.
Title: Molecular subtypes and genetic diagnostics in B-cell acute lymphoblastic leukemia
Authors: Roberta S. Azevedo, L. Jeffrey Medeiros, Sanam Loghavi, Nicholas J. Short
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Next, Wei J. Wang, Joseph D. Khoury, L. Jeffrey Medeiros, Hong Fang and Wei Wang wrote about T-ALL, with a practical approach to diagnosis, differential diagnosis, and subtype classification using flow and IHC.
Title: Practical approaches to the diagnosis and differential diagnosis of T-lymphoblastic leukemia/lymphoma
Authors: Wei J. Wang, Joseph D. Khoury, Hong Fang, L. Jeffrey Medeiros, Wei Wang
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Next, Sa A Wang and Vicky Leventaki take us through an MPAL tour emphasizing the practical application of lineage assignment criteria and discuss the genomic underpinnings of this MPAL, including ZNF384r, BCL11B, BCR::ABL1 and more.
Title: Mixed phenotype acute leukemia: Lineage assignment, immunophenotypic classification and genetic insights
Authors: Vasiliki Leventaki and Sa A. Wang
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Next, AML in the spotlight , First Kamran Mirza, Julia Anderson-Calleja, et al, sprovide a beautiful depiction of how the cytomorphologic findings correlate with genotype. Major shoutout to all pathologist out there .. single cell sequencing is hot and all… but have you every diagnosed DEK:: NUP214 with your naked eyes??
Next up, Derek Loneman, Valentina Nardi and Rob Hasserjian write a practical guide to contemporary AML diagnosis and classification. Their review traces the evolution of AML classification from the FAB to present. Its soooo good.
Title: Contemporary approach to diagnosis and classification of acute myeloid leukemia
Authors: Derek M. Loneman, Valentina Nardi, Robert P. Hasserjian
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Next up is one of my favorites: Myeloid Sarcoma. The one and only AK Eisfeld and L. Jeffrey Medeiros write a tour de force on MS, proposing a paradigm shift in the way we think about this disease!
spoiler alert: RAS RAS RAS.
This one has a special place in my .. b/c what better than your bestie and your boss writing together about a topic you love?
Title: Myeloid sarcoma: Clinical, Pathologic, and Molecular Findings
Authors: Ann-Kathrin Eisfeld and L.Jeffrey Medeiros
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Pivoting to CMML.. Guillermo Montalban-Bravo and yours truly write about oligomonocytic CMML… if you know me at all.. you know I’ve been obsessed with this topic for a while.. so this was quite satisfying to write.
Title: Chronic myelomonocytic leukemia revisited: A comprehensive review with emphasis on the oligomonocytic subtype
Authors: Sanam Loghavi and Guillermo Montalban-Bravo
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The final 6 reviews address the technologies that have made the precision medicine era in acute leukemia possible.
Title: The role of advanced molecular diagnostics in informing targeted therapies for AML
Authors: Jennifer Marvin-Peek, Sanam Loghavi, Ghayas C. Issa, Naval G. Daver, Tapan M. Kadia, Farhad Ravandi, Courtney D. DiNardo
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G Tang, Q Wei, M Klausner, YS. Zou and Gokce Altay Toruner write about Optical genome mapping (OGM) and how it has improved our detection of clinically relevant CG alterations in myeloid neoplasms.
Title: Optical genome mapping in myeloid neoplasms
Authors: Guilin Tang, Qing Wei, Melanie Klausner, Ying S. Zou, Gokce A. Toruner
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Next up.. everyone’s favorite topic: MRD.. A master review by the one and only Jad Othman, George Mason and Ameya Hanamshet a, on Multimodal MRD detection in AML: From technology to clinical integration …. Please do yourself a favor and read this.. it is gold!
Title: Multimodal measurable residual disease detection in acute myeloid leukemia: From technology to clinical integration
Authors: George Mason, Ameya Hanamshet, Jad Othman
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Who better than the queen of single cell sequencing in AML.. Linde Miles to write about the application of single-cell technologies to AML with Annabelle Anandappa and Wenbin Xiao they write this marvelous piece of work.. please check it out.. you will love this one.
Title: Single cell sequencing in acute myeloid leukemia: Linking genotype to functional phenotype for precision risk stratification and treatment decisions
Authors: Annabelle J. Anandappa, Wenbin Xiao, Linde A. Miles
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Next up.. cell therapies, Iman Sarami and L. Jeffrey Medeiros walk us through CAR-T cell therapy and its complications, and the role of the pathologist in their diagnosis.
Title: CAR-T cell therapy and its complications: Role of the pathologist in diagnosis
Authors: Iman Sarami and L. Jeffrey Medeiros
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And last but certainly not least.. the issue would not be complete without this fantastic review on the emerging role of AI in diagnostics in myeloid malignancies by Pravin Patel and Olga Pozdnyakova.
Title: Advances in digital pathology and artificial intelligence in the diagnosis of myeloid neoplasms
Authors: Pravin Patel and Olga Pozdnyakova
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Finally.. I’d like say how grateful we are to each and every one of the authors who contributed to this issue and shared their expertise… what a privilege to be able to host this hemepath/leukemia soirée. I admire you all so much!!”
Other articles featuring Sanam Loghavi on OncoDaily.
