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Yan Leyfman: Can bendamustine replace Flu/Cy as lymphodepleting chemotherapy before CAR-T in relapsed/refractory NHL
Yan Leyfman
Jun 17, 2025, 23:49

Yan Leyfman: Can bendamustine replace Flu/Cy as lymphodepleting chemotherapy before CAR-T in relapsed/refractory NHL

Yan Leyfman, Co-founder and Executive Director of MedNews Week, shared a post on LinkedIn:

“New Study Alert: CAR-T Prep Reimagined! Can bendamustine replace Flu/Cy as lymphodepleting chemotherapy before CAR-T in relapsed/refractory NHL?
In a large real-world study (n=265), bendamustine showed:
  •  Comparable OS and PFS
  •  Less severe neutropenia (71% vs. 17%)
  •  Greater feasibility in outpatient settings
A promising alternative amidst global fludarabine shortages. Time to rethink how we prep for CART therapy? Kaplan-Meier and Cox models adjusted for CAR-T product, year, subtype, and steroid use.”

Title: Comparative Efficacy of Bendamustine Versus Fludarabine/Cyclophosphamide for Lymphodepletion Before Chimeric Antigen Receptor T-Cell Therapy in Lymphoma

Authors: Uttam K. Rao, Navneet S. Majhail, Betsy Blunk, Karin Abernathy, Carlos Bachier, Vikas Bhushan, Jose Carlos Cruz, Mohammed Elayan, Tara Gregory, Charles F. LeMaistre, Shahbaz A. Malik, Casey Martin, Meredith Mattlin, Gabrielle Blade, Michael B. Maris, John Mathews, Luke Mountjoy, Jeremy M. Pantin, Aravind Ramakrishnan, Paul Shaughnessy, Minoo Battiwalla

Read the Full Article.

Yan Leyfman

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Aravind Ramakrishnan Betsy Blunk cancer Carlos Bachier Casey Martin Charles F. LeMaistre Gabrielle Blade Jeremy M. Pantin John Mathews Jose Carlos Cruz Karin Abernathy Luke Mountjoy Meredith Mattlin Michael B. Maris Minoo Battiwalla Mohammed Elayan Navneet S. Majhail OncoDaily Oncology Paul Shaughnessy Shahbaz A. Malik Tara Gregory Uttam K. Rao Vikas Bhushan
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