Aakash Desai: The PLAN Study Shows Liquid Biopsy is Faster, Accurate, and Cost-Effective
Aakash Desai, Assistant Professor and Associate Director of Phase 1 and Precision Oncology Program at the UAB O’Neal Comprehensive Cancer Center, shared a post on LinkedIn:
“The PLAN Study Shows Liquid Biopsy is Faster, Accurate, and Cost-Effective!
A pilot clinical trial published in the European Journal of Cancer! This research investigated a “plasma-first” approach for next-generation sequencing (NGS) in newly diagnosed advanced Non-Small Cell Lung Cancer (NSCLC) patients in Ireland.
The results are highly impactful:
- Speed: Liquid biopsy genotyping (LBG) significantly reduced the time to genomic diagnosis by a median of 21 days compared to traditional tissue biopsy (TBG). This means faster access to critical treatment decisions for patients.
- Accuracy: We observed a remarkable 90% concordance between LBG and TBG in identifying genomic variants.
- Cost-Effectiveness: LBG proved to be less than half the cost of TBG (€1135 vs. €2404) and led to overall cost savings of over €20,000 within the study cohort. This highlights its potential to optimize healthcare resource allocation.
This study provides strong evidence that integrating a “plasma-first” approach for NGS into clinical practice can lead to substantial clinical benefits and financial savings in public healthcare systems. It offers a vital step forward in ensuring more timely and efficient care for NSCLC patients.
Full details can be found in the European Journal of Cancer article.”
Title: Clinical benefit and cost of plasma-first next-generation sequencing in patients with newly diagnosed advanced non-small cell lung cancer in Ireland: The PLAN study
Journal: European Journal of Cancer
Authors: David O Reilly, Anthony O Grady, Conor Hayes, Laura Piggott, Ruaidhri Keane, Orla Fitzpatrick, Michael Conroy, Nicholas Kruseman Aretz, David Synnott, Rachel Dillon, Gavin P Dowling, Daniel J. Ryan, Emmet O’Brien, Ross Morgan, Oscar Breathnach, Liam Grogan, Patrick Morris, Megan Greally, Minh Yuen Teo, Adrian Murphy, Gillian Ryan, Ian Counihan, Cliona Ryan, Helen Barrett, Ann-Marie O’Shea, Sinead Cuffe, Grzegorz Korpanty, Lisa Prior, Martin P. Barr, Stephen Finn, Cathal O Brien, Sarah McCarron, Rob Cummins, Sinead Toomey, Catriona M. Dowling, Siobhan Glavey, Bryan T Hennessy, Jan Sorensen, Kathleen Bennett, Parthiban Nadarajan, Brendan Doyle, Jarushka Naidoo
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