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Oscar Tahuahua: Rational combos and next-gen RAS inhibitors are key
Oscar Tahuahua/X
May 4, 2025, 02:34

Oscar Tahuahua: Rational combos and next-gen RAS inhibitors are key

Oscar Tahuahua, Medical Oncology fellow at the National Cancer Institute of Mexico, shared on X about a recent paper by Richard Y. Ebright et al. published in Cancer Discovery:

“RAS Inhibition: Response and Resistance
– Primary (10–20%): KEAP1, PI3K, TP53, SMARCA4 mutations.
– Acquired (~60%): KRAS muts (25–30%), RTKs (20–25%), PI3K (10–15%), MYC, EMT and MAPK pathway.
Rational combos and next-gen RAS inhibitors are key.”

Oscar Tahuahua

Response and Resistance to RAS Inhibition in Cancer

Authors: Richard Y. Ebright et al

Oscar Tahuahua

Learn more about RAS pathway in cancer on OncoDaily.

AACR Alice T Shaw Andrew J. Aguirre Cancer Discovery Julien Dilly National Cancer Institute of Mexico Oscar Tahuahua RAS Inhibition Richard Y. Ebright
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