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Oscar Tahuahua: Genomic Chaos in Sarcomatoid Renal Cell Carcinoma
Oscar Tahuahua/X
Aug 10, 2025, 21:48

Oscar Tahuahua: Genomic Chaos in Sarcomatoid Renal Cell Carcinoma

Oscar Tahuahua, Medical Oncology Fellow at the National Cancer Institute of Mexico, shared a post on X about a recent paper by Nicholas J. Salgia et al. published in Cancer Cell:

“Genomic chaos (↑TMB, CDKN2A/B loss, TP53 muts, genomic instability) fuels an IFN γ-rich, PDL1 high, CD8+ rich TME.

ICIs lead to deep and durable responses in approximately 50–60% ”

Oscar Tahuahua

Title: Comprehensive tumor-immune profiling reveals mediators of paradoxical immune sensitivity in sarcomatoid renal cell carcinoma

Journal: Cancer Cell

Authors: Nicholas J. Salgia, Adil Khan, Wilhelm M. Aubrecht, Gavin C. Twoey, Jacky Chow, Kristopher Attwood, Han Yu, Jessie L. Chiello, Nathaniel Hansen, Brianna J. Wasik, Benjamin D. Mercier, Hedyeh Ebrahimi, Luis Meza, Orla Maguire, Michalis Mastri, Cassandra Whalen, Hans Minderman, Patrick Pirrotte, Sara Byron, Elizabeth A. Repasky, Prashant K. Singh, Wiam Bshara, Jianmin Wang, A.J. Robert McGray, Scott I. Abrams, Bo Xu, Kevin H. Eng, Mark D. Long, Sumanta K. Pal, Eric C. Kauffman, Jason B. Muhitch

Read the full article.

Oscar Tahuahua

More posts featuring Oscar Tahuahua on OncoDaily.

A.J. Robert McGray Adil Khan Benjamin D. Mercier Bo Xu Brianna J. Wasik cancer Cassandra Whalen Elizabeth A. Repasky Eric C. Kauffman Gavin C. Twoey Han Yu Hans Minderman Hedyeh Ebrahimi Jacky Chow Jason B. Muhitch Jessie L. Chiello Jianmin Wang Kevin H. Eng Kristopher Attwood Luis Meza Mark D Long Michalis Mastri Nathaniel Hansen Nicholas J. Salgia OncoDaily Oncology Orla Maguire Patrick Pirrotte Prashant K. Singh RCC Sara Byron Sarcomatoid Renal Cell Carcinoma Scott I. Abrams Sumanta K. Pal Wiam Bshara Wilhelm M. Aubrecht
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