Oscar Tahuahua: Genomic Chaos in Sarcomatoid Renal Cell Carcinoma
Oscar Tahuahua, Medical Oncology Fellow at the National Cancer Institute of Mexico, shared a post on X about a recent paper by Nicholas J. Salgia et al. published in Cancer Cell:
“Genomic chaos (↑TMB, CDKN2A/B loss, TP53 muts, genomic instability) fuels an IFN γ-rich, PDL1 high, CD8+ rich TME.
ICIs lead to deep and durable responses in approximately 50–60% ”
Title: Comprehensive tumor-immune profiling reveals mediators of paradoxical immune sensitivity in sarcomatoid renal cell carcinoma
Journal: Cancer Cell
Authors: Nicholas J. Salgia, Adil Khan, Wilhelm M. Aubrecht, Gavin C. Twoey, Jacky Chow, Kristopher Attwood, Han Yu, Jessie L. Chiello, Nathaniel Hansen, Brianna J. Wasik, Benjamin D. Mercier, Hedyeh Ebrahimi, Luis Meza, Orla Maguire, Michalis Mastri, Cassandra Whalen, Hans Minderman, Patrick Pirrotte, Sara Byron, Elizabeth A. Repasky, Prashant K. Singh, Wiam Bshara, Jianmin Wang, A.J. Robert McGray, Scott I. Abrams, Bo Xu, Kevin H. Eng, Mark D. Long, Sumanta K. Pal, Eric C. Kauffman, Jason B. Muhitch
More posts featuring Oscar Tahuahua on OncoDaily.
-
Challenging the Status Quo in Colorectal Cancer 2024
December 6-8, 2024
-
ESMO 2024 Congress
September 13-17, 2024
-
ASCO Annual Meeting
May 30 - June 4, 2024
-
Yvonne Award 2024
May 31, 2024
-
OncoThon 2024, Online
Feb. 15, 2024
-
Global Summit on War & Cancer 2023, Online
Dec. 14-16, 2023