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Laura Bukavina: The Influence of Bladder Microbiome on Intravesical Chemotherapy Response in Bladder Cancer
Laura Bukavina/X
Aug 9, 2025, 18:57

Laura Bukavina: The Influence of Bladder Microbiome on Intravesical Chemotherapy Response in Bladder Cancer

Laura Bukavina, Urologic Oncologist at Cleveland Clinic, shared a post on X:

“New pub alert. The bladder microbiome may influence intravesical chemotherapy response in bladder cancer. We tested uropathogenic E. coli (UPEC) and gemcitabine
Results>

  •  Ecoli can enter tumor cells (of course)
  •  Inactivate gemcitabine → converting it to an inactive metabolite (dFdU)
  •  Reduce chemo’s ability to kill cancer cells.”

Title: Bladder cancer microbiome and its association with chemoresponse

Authors: Rashida Ginwala, Laura Bukavina, Mohit Sindhani, Erika Nachman, Suraj Peri, Jodie Franklin, John Drevik, Sarah Christianson, Daniel M. Geynisman, Alexander Kutikov, Philip H. Abbosh

Read the Full Article.

Laura Bukavina

More posts featuring L. Bukavina.

Alexander Kutikov bladder cancer cancer Daniel M. Geynisman Erika Nachman Jodie Franklin John Drevik Laura Bukavina Mohit Sindhani OncoDaily Oncology Philip H. Abbosh Rashida Ginwala Sarah Christianson Suraj Peri
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