aacr.org
Aug 5, 2025, 17:16
Jean-Charles Soria: Cancer Cachexia – A Lethal, Underdiagnosed Syndrome
Jean-Charles Soria, SVP and Oncology Therapeutic Area Head at Amgen, shared a post on LinkedIn:
“Cancer cachexia = an underdiagnosed, lethal syndrome.
· Affects up to 80% in pancreatic CA, 40% in lung.
· It’s not just weight loss—think systemic inflammation, altered metabolism, fat/muscle wasting.
· GDF-15, IL-6, activin A are key molecular drivers.
· A major unmet need in cancer patients.”
Title: Cancer-Associated Cachexia: Bridging Clinical Findings with Mechanistic Insights in Human Studies
Authors: Kexin Koh, Rachel Scott, Elizabeth M. Cespedes Feliciano, Tobias Janowitz, Marcus D. Goncalves, Eileen P. White, Barry J.A. Laird, Kerstin Haase, Mariam Jamal-Hanjani
Read the Full Article.
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