Enrique Grande, One Oncology Madrid Program Director of Quirónsalud, Adjunct Professor at The University of Texas MD Anderson Cancer Center, shared on X:
“High IL-6/CRP tracks with SPP1⁺ macrophage-rich, T-cell-suppressed tumors in urothelial cancer across ICB cohorts.
Blood biomarkers linking to an immunosuppressive TME – and a potentially targetable axis of resistance to immunotherapy.”
Title: A Tumor-Promoting Inflammatory SPP1+ Macrophage–IL6–CRP Axis Drives Immune Dysfunction in Bladder Cancer
Authors: Michelle A. Tran, Byuri Angela Cho, Sudeh Izadmehr, Seong-Keun Yoo, Dina Youssef, Jonathan F. Anker, Adam M. Farkas, Igor Figueiredo, Karen Lee, Aparna Ananthanarayanan, Sreekumar Balan, Sayali Onkar, Romain Banchereau, Saurabh Gupta, Aparna Chhibber, Li Wang, Kristin G. Beaumont, Ziao Li, Monica Garcia-Barros, Mesude Bicak, Carlos Cordon-Cardo, Rachel Brody, Seunghee Kim-Schulze, Kobe Yuen, Sanjeev Mariathasan, Saad O. Atiq, Tolulope T. Adeyelu, Andrew Elliott, Pedro Barata, Rana R. McKay, Sacha Gnjatic, Edgar Gonzalez-Kozlova, Reza Mehrazin, Amir Horowitz, John P. Sfakianos, Diego Chowell, Matthew D. Galsky, Nina Bhardwaj
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