Article of the Week, Suggested by the BPDCN International Registry
Immune Oncology Research Institute shared a post on LinkedIn:
“Article of the Week Suggested by the BPDCN International Registry-Astghik Voskanyan
Blastic Plasmacytoid Dendritic Cell Neoplasm: A Comprehensive Review of the Disease, Central Nervous System Presentations, and Treatment Strategies!
Despite advancements in the understanding and treatment of BPDCN, managing CNS involvement remains challenging due to its rare occurrence and evolving diagnostic strategies. Prophylactic lumbar punctures are not standard, complicating CNS monitoring. Studies on key therapies like Tagraxofusp and Venetoclax excluded patients with CNS presentations, limiting insights into treatment for this subset. Tracking CNS relapse after HSCT is critical to understanding its curative potential. Although IT therapy is currently the only specific treatment for CNS involvement in BPDCN, this area remains a significant gap in drug development, and clinical trials are needed to address it.”
Authors: Shefali Mehra, Justin Taylor.
Immune Oncology Research Institute (IMMONC), established in 2022, is a non-profit, independent, patient-centered research institute. The mission of IMMONC is to advance the cancer knowledge and care through breakthrough scientific research, to integrate innovative immune-oncology therapies into the clinical practice for different types of cancers, to generate and collect clinical data for the identification of new therapeutic targets, developing predictive models and optimizing patient outcomes, to increase the availability and accessibility of those discoveries for the cancer patients, to create a world-class professional environment, to attract the brightest minds in cancer field and to train the next generation researchers.
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