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Erman Akkus: HER2 and mCRC on Journal of Clinical Oncology
Mar 16, 2024, 20:07

Erman Akkus: HER2 and mCRC on Journal of Clinical Oncology

Erman Akkus, Medical Oncology Fellow at Ankara University, shared on X/Twitter:

“HER2 and mCRC on Journal of Clinical Oncology:

  • HER2 gene expression is predictive and prognostic
  • High expression -> better survivals
  • Low expression -> favors bevacizumab (vs cetuximab)

HER2 amplification is not predictive or prognostic.

  • 925 patients, samples from CALGB)/SWOG 80405 trial
  • first line
  • High HER2 expression: longer PFS (11.6 v 10 months, P = .012) and OS (32 v 25.3 months, P = .033), independent of treatment
  • Low expression group, cetuximab ->. worse PFS (HR, 1.38 [1.12 to 1.71]; P = .0027) and OS (HR, 1.28 1.02 to 1.59]; P = .03) compared with bevacizumab.”

Visit the article website.
Source: Erman Akkus/X