Erman Akkus: Does primary tumor resection prolong OS in inoperable synchronous metastatic CRC?

Erman Akkus, Medical Oncology Fellow at Ankara University, shared on X:

“Does primary tumor resection (PTR) prolong (OS) in inoperable synchronous metastatic CRC? SYNCHRONOUS and CCRe-IV trials Journal of Clinical Oncology.

Negative study

• Patients with tumor-related symptoms or diagnostic findings requiring primary surgery (eg, lower GI bleeding requiring transfusion, bowel obstruction, tumor perforation, or intractable pain) excluded.
• PTR vs no PTR, OS: 16.7 months (95% CI, 13.2 to 19.2) vs 18.6 months (16.2 to 22.3) (P = .191).
• Serious adverse events more common in No PTR (10.2% vs 18.0%; P = .027)”

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Source: Erman Akkus/X