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Marco Donia: The ‘Influencers’ of Cancer Immunotherapy do not affect immunotherapy outcomes

Photo from Marco Donia/LinkedIn

Mar 1, 2024, 17:25

Marco Donia: The ‘Influencers’ of Cancer Immunotherapy do not affect immunotherapy outcomes

Marco Donia, Associate Professor at National Center for Cancer Immune Therapy, Denmark, shared on LinkedIn:

“The ‘Influencers’ of Cancer Immunotherapy

NSAIDs (Eur J Cancer, Apr 2024) do not affect immunotherapy outcomes. NSAIDs are not influencers; they can be safely used with anti-PD-1.

What are the Influencers of Cancer Immunotherapy?

Factors that can (potentially) improve or impair the effects of Cancer Immunotherapy such as:

1. Drugs:

Antibiotics (article 1 or article 2)
Paracetamol
Beta-blockers
Proton pump inhibitors
Immunosuppressive drugs – for obvious reasons

2. Environmental Factors:

3. Psychosocial Factors:

Emotional Distress

4. Diet and Body Composition:

Dietary Fibers, Probiotics, and Microbiome (article 1 or article 2)
Body Mass Index
Physical Activity

5. Sex

6. Many others – please share in the comments section!

Sara Valpione and collaborators investigated the prognostic and predictive value for the usage of non-steroidal anti-inflammatory drugs in the EORTC 1325/KEYNOTE-054 phase III trial of pembrolizumab versus placebo in resected high-risk stage III melanoma.
Main finding: No association with recurrence-free survival, distant metastasis-free survival, or immune-related adverse events This paper is from a series of manuscripts (manuscript 1, manuscript 2) investigating associations of drugs usage and clinical outcomes in the KN-054 trial.

NSAIDs=non-steroidal anti-inflammatory drugs (like diclofenac, aspirin, ibuprofen).

Marco Donia: The 'Influencers' of Cancer Immunotherapy do not affect immunotherapy outcomes