Alessandro Inno: A case of a very elderly patient with MET-exon 14 mutant NSCLC with meaningful and durable benefit from first-line tepotinib, with an acceptable safety profile

Quoting Alessandro Inno, Consultant Medical Oncologist at IRCCS Ospedale Sacro Cuore Don Calabria, on LinkedIn:

”Tepotinib and capmatinib are MET inhibitors approved by European Medicines Agency for patients with metastatic NSCLC harboring MET exon-14 skipping mutations, but only after receiving immunotherapy and/or platinum-based chemotherapy. However, MET exon-14 skipping mutations ofter occurr in elderly patients that may be unfit for immunotherapy and/or chemotherapy, although they may still tolerate target therapy. Moreover, growing evidence suggest that MET inhibitors are a valuable option also as first-line treatment. Thus, we believe that the approval of MET inhibitors only for pretreated patients may limit the access to an active treatment for those elderly patients with metastatic MET-exon 14 mutant NSCLC that are unfit to receive first-line immunotherapy and/or chemotherapy.

At this regard, we discuss the case of a very elderly patient with MET-exon 14 mutant NSCLC that achieved a meaningful and durable benefit from first-line tepotinib, with an acceptable safety profile.”

For the article click here.
Source: Alessandro Inno/LinkedIn