Jean-Charles Soria: ecDNA fuels cancer progression
Jean-Charles Soria, Senior Vice President and Oncology Therapeutic Area Head at Amgen, shared a post on X:
“ecDNA fuels cancer progression: large, mobile circles of DNA in tumors drive high oncogene copies & rapid genetic changes. Their random spread during cell division increases treatment resistance & tumor evolution. Determining therapeutic vulnerabilities & identifying target compounds to limit ecDNA evolution could open impactful new therapeutic horizons.”
Origins and impact of extrachromosomal DNA
Authors: Chris Bailey, Oriol Pich, Kerstin Thol, Thomas B. K. Watkins, Jens Luebeck, Andrew Rowan, Georgia Stavrou, Natasha E. Weiser, Bhargavi Dameracharla, Robert Bentham, Wei-Ting Lu, Jeanette Kittel, S. Y. Cindy Yang, Brooke E. Howitt, Natasha Sharma, Maria Litovchenko, Roberto Salgado, King L. Hung, Alex J. Cornish, David A. Moore, Richard S. Houlston, Vineet Bafna, Howard Y. Chang, Serena Nik-Zainal, Nnennaya Kanu, Nicholas McGranahan, Genomics England Consortium, Adrienne M. Flanagan, Paul S. Mischel, Mariam Jamal-Hanjani & Charles Swanton
Jean-Charles Soria serves as Amgen’s senior vice president of Oncology within Global Development. He is a medical oncologist and a professor of medicine at Paris-Saclay University. From 2017 to 2019, he was the senior vice president of Research and Development in Oncology at AstraZeneca. Additionally, Soria has authored or co-authored over 670 articles in leading international journals and has been recognized as one of the world’s most influential research scientists.
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