Pivotal trial of extended lymphadenectomy vs standard procedure for muscle-invasive bladder cancer

The New England Journal of Medicine shared an article by Seth P. Lerner on X:

“In patients with muscle-invasive bladder cancer, extended lymphadenectomy did not improve disease-free or overall survival as compared with the standard procedure and was associated with higher morbidity and mortality.”

Shilpa Gupta reshared the post on X, adding:

“Congrats Seth P. Lerner and entire SWOG Cancer Research Network S1011 team on this pivotal trial of extended lymphadenectomy vs standard procedure. This Herculean effort settles the issue for good.”

Title: Standard or Extended Lymphadenectomy for Muscle-Invasive Bladder Cancer.

Authors: Seth P. Lerner, Catherine Tangen, Dr.P.H, Robert S. Svatek, Siamak Daneshmand, Kamal S. Pohar, Eila Skinner and Anne Schuckman.

Source: NEJM/X and Shilpa Gupta /X

Dr. Shilpa Gupta is the Director of Genitourinary Oncology, a staff member in Hematology and Oncology and a Professor of Medicine at Cleveland Clinic. Dr. Gupta’s extensive research focuses on novel drug development and biomarkers of response/resistance in bladder cancer, contributing to numerous published works and leadership roles in clinical trials.