![TIP60 and chemoresistance in cancer cells exposed to DNA damaging agent](https://oncodaily.com/pub/uploads/2024/07/IMG_3909.jpeg)
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Jul 10, 2024, 00:52
TIP60 and chemoresistance in cancer cells exposed to DNA damaging agent
Andrew Deans, Associate Director at St Vincent’s Institute of Medical Research, shared a paper by Hengxing Chen, et al. on X:
“TIP60 acts as an ATM-dependent lysine lactylation transferase.
NBS1 lactylation at K388 on the NBS1-MRE11 interaction interface promotes DNA repair and chemoresistance in cancer cells exposed to DNA damaging agents.”
Source: Andrew Deans/X
NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance.
Authors: Hengxing Chen, Yun Li, Huafu Li, Xiancong Chen, Huafeng Fu, Deli Mao, Wei Chen, Linxiang Lan, Chunming Wang, Kaishun Hu, Jia Li, Chengming Zhu, Ian Evans, Eddie Cheung, Daning Lu, Yulong He, Axel Behrens, Dong Yin and Changhua Zhang.
Andrew Deans
Axel Behrens
cancer
Cancer Cells
Changhua Zhang
Chengming Zhu
Chunming Wang
Daning Lu
Deli Mao
DNA repair
Dong Yin
Eddie Cheung
Hengxing Chen
Huafeng Fu
Huafu Li
Ian Evans
Jia Li
K388
Kaishun Hu
Linxiang Lan
lysine lactylation transferase
NBS1 lactylation
OncoDaily
Oncology
TIP60
Wei Chen
Xiancong Chen
Yulong He
Yun Li