Jun 1, 2025, 18:36

Notice of Special Interest: Research on HIV-associated Malignancies

The National Cancer Institute seeks R01 and R21 applications to advance understanding of cancer in people with HIV—focusing on how HIV infection and co‐infections drive malignancy risk, pathogenesis, diagnosis, and treatment outcomes. Projects may explore mechanistic studies, biomarker discovery, epidemiology, and model development tailored to HIV‐associated cancers.

Eligibility Criteria:

Applicant Organizations:
- U.S. or foreign institutions eligible under:
  - R01 (Parent R01 Clinical Trial Not Allowed; PA-20-185)
  - R21 (Parent R21 Clinical Trial Not Allowed; PA-20-195)
  - R21 (HIV‐associated NCD Research in LMICs; PAR-23-191)
Investigator Qualifications:
- PD/PI must have relevant expertise in HIV, cancer biology, epidemiology, or related disciplines.
- Early Stage Investigators and established investigators are both encouraged.

Funding Details:

Activity Codes & Parent FOAs:
- R01 (Clinical Trial Not Allowed): PA-20-185
- R21 (Clinical Trial Not Allowed): PA-20-195
- R21 (Clinical Trial Optional, LMIC Focus): PAR-23-191
Budget & Project Period:
- R01: Follow R01 budget guidelines (up to $500 000 direct costs/year, as allowed by FOA; up to 5 years).
- R21: Follow R21 budget guidelines (up to $275 000 total costs over 2 years, with no more than $200 000 in any single year).
Special Instructions:
- Include “NOT-CA-23-070” in box 4B (Agency Routing Identifier) of the SF424 (R&R) form. Applications missing this identifier will be withdrawn.
- Applications not addressing HIV‐associated malignancies as described will be withdrawn.

Deadline:

Subsequent Due Dates: Per parent FOA schedules through September 8, 2026
Expiration Date: September 8, 2026

Where to Go for Further Information:

NOSI Full Text
Application Guide (SF424 R&R Instructions).
Scientific/Research Contacts (NCI):
- Basic Science Research: Dr. Elizabeth Read-Connole (240-726-6190, [email protected])
- Malignant Complications of HIV/AIDS:
  - Dr. Geraldina Dominguez (240-781-3291, [email protected])
  - Dr. Johnan Kaleeba (240-781-3326, [email protected])
- Epidemiology & Digital Epidemiology (AI/ML): Vaurice Starks (301-624-1299, [email protected])
- Epigenetics: Dr. Mukesh Verma (240-276-6889, [email protected])
Grants Management Contact (NCI): Crystal Wolfrey (240-276-6277, [email protected])