CIOT25 Highlights by Stephen V Liu

The 13th International Conference on Thoracic Oncology (CIOT 2025) took place in Venice from June 19th to June 20th, 2025. The event was organized by the Italian Association of Thoracic Oncology (AIOT) and chaired by Filippo de Marinis. The faculty included approximately 90% international speakers involved in clinical research, presenting new clinical data in thoracic oncology.

The conference was held at the Hotel Monaco and Grand Canal, located near Piazza San Marco in Venice. The two-day program included lectures, round tables, debates, and face-to-face sessions covering targeted therapies, immunotherapy, and clinical research updates on metastatic and non-metastatic thoracic cancers.

The event was scheduled immediately after the ASCO meeting and provided clinical research updates and opportunities for international collaboration. Italian attendees could earn CME credits by attending the full conference and completing the required educational activities.

Stephen V Liu, Director of Thoracic Oncology and Associate Professor of Medicine at Georgetown University, shared some insights from CIOT25.

Starting CIOT25 with Drs. Filippo de Marinis and Cesare Gridelli

“Starting CIOT25 with Drs. Filippo de Marinis and Cesare Gridelli in Venice. A privilege to discuss recent paradigm changes in lung cancer with expert friends.”

Discussion on targeted therapy with global experts

“Discussion on targeted therapy with global experts Antonio Passaro, Lorenza Landi, Nicolas Girard, Tony Mok, Alexander Drilon, Ben Solomon – looking beyond the data, what outcomes are most important to our patients?”

Tony Mok’s discussion on EGFR at CIOT25

“Dr. Tony Mok discusses EGFR at CIOT25. Emerging combinations like MARIPOSA and FLAURA2 improving outcomes – key is patient selection. Chemo-IO is out based on CM722 and KN789 but HARMONi could change things if OS superior. ADCs in 3L instead of 2L?”

Nicolas Girard discusses EGFR exon 20 insertions

“Dr. Nicolas Girard discusses EGFR exon 20 insertions at CIOT25 – amivantamab plus chemo (PAPILLON) is our standard but outcomes vary by specific mutation. New agents to watch include furmonertinib, sunvozertinib, zipalertinib, and more in the pipeline!”

Massive progress in ALK therapy for NSCLC at CIOT25 by Dr. Ben Solomon

“Dr. Ben Solomon shows the massive progress we have seen in ALK therapy for NSCLC at CIOT25. Profound PFS benefit with lorlatinib in CROWN. Will NVL-655 / neladalkib eclipse those marks?”

Alexander Drilon at CIOT25 clearly favoring taletrectinib as 1L for ROS1 NSCLC

“Dr. Alexander Drilon at CIOT25 clearly favoring taletrectinib as 1L for ROS1 NSCLC – potential and better tox profile. NVL-520 zidesamtinib poised to potentially be best in class. For RET, after selpercatinib or pralsetinib, few options. EP0031 is one in development.”

Suresh S. Ramalingam outlining the role that targeted therapy plays in early stage EGFR NSCLC

“Dr. Suresh S. Ramalingam at CIOT25 outlines the role that targeted therapy plays in early stage EGFR NSCLC. ADAURA shows the benefit of osimertinib after surgery. NEOADAURA shows modest MPR but unlikely to impact OS. LAURA shows benefit after chemoradiation- but is it a cure?”

Dr Reck Revisits KEYNOTE 024 with CIOT25 Insights on Long Term PD L1 Impact

“Dr. Martin Reck at CIOT25 reflects back on KEYNOTE 024 first presented at ESMO 2016 and now, paradigm shifting long term survival data with PD(L)1 monotherapy. Benefit extends to PS2 (IPSOS). Less for those with no smoking history, regardless of PDL1 expression.”

Brilliant overview of novel immunotherapy strategies in NSCLC by Solange Peters

“Dr. Solange Peters at CIOT25 gives a brilliant overview of novel immunotherapy strategies in NSCLC. Bispecifics leading the way – ivonescimab, BNT327. Will we see vaccines improve outcomes? Tedopi to be explored in ARTEMIA trial and several mRNA vaccines showing promise.”

Great discussion on immunotherapy in NSCLC and how to take the next step

“Great discussion on immunotherapy in NSCLC and how to take the next step with Drs. Nicola Normanno, Cesare Gridelli, Martin Reck,  Jon Zugazoitia, Solange Peters, Tony Mok at CIOT25.”

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