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Amol Akhade: CRC Screening Face-Off: Stool vs Blood
Jul 5, 2025, 19:18

Amol Akhade: CRC Screening Face-Off: Stool vs Blood

Amol Akhade, Consultant Medical Oncologist Hemato Oncologist at Suyog Cancer Clinics, shared on X:

“CRC Screening Face-Off: Stool vs Blood
Not all non-invasive tests are created equal.
Let’s break it down:

CRC Sensitivity

  • Cologuard Plus: 95%
  • ColoSense: 94%
  • Shield (blood): 80–83%
  • FIT: 67–91%

Advanced Adenoma Detection (PREVENTION!)

  • ColoSense: 46%
  • Cologuard: 43%
  • FIT: 20–30%
  • Shield: 13–16%

High-Grade Dysplasia

  • Cologuard: 74%
  • FIT: 47%
  • Shield: 23%
  • ColoSense: Not Available

Specificity

  • FIT: 95%
  • Shield: 90%
  • Cologuard: 91–94%
  • ColoSense: 88%

Verdict:
Blood-based cfDNA is convenient but underperforms where it matters – early detection of pre-cancer.
Cologuard and ColoSense are clear leaders in prevention.

If we want to prevent, not just detect, CRC – stool-based testing still beats.”

Amol Akhade

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