Galip Can Uyar: Can Metformin Improve Outcomes in Metastatic Hormone-sensitive Prostate Cancer?
Galip Can Uyar, Medical Doctor at Etlik City Hospital, shared a post on X:
“Just published in The Lancet Oncology: Can metformin, a cheap and widely used antidiabetic, improve outcomes in metastatic hormone-sensitive prostate cancer (mHSPC)?
In this large phase 3 STAMPEDE trial (n=1874), adding metformin to standard of care did not improve OS in the overall population (HR: 0.91, p=0.15). However, in patients with high-volume disease, metformin showed a significant survival benefit (HR: 0.79, p=0.0072).
Importantly, metformin also mitigated ADT-induced metabolic toxicity (↓ weight gain, glucose, LDL, HbA1c)—across all subgroups. A low-cost intervention with dual metabolic and potential oncologic impact?”
Title: Metformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol
Authors: Silke Gillessen, Laura Murphy, Nicholas D James, Ashwin Sachdeva, Omar El-Taji, Hoda Abdel-Aty, Amanda I Adler, Claire Amos, Gerhardt Attard, Mohini Varughese, Joanna Gale, Simon Brown, Narayanan Srihari, Alison J Birtle, Mick Brown, Kitty Chan, Simon Chowdhury, William Cross, David P Dearnaley, Omar Din, Peter Dutey-Magni, Duncan C Gilbert, Clare Gilson, Struan Gray, Emily Grist, Uschi Hofmann, Andrew M Hudson, Yatin Jain, Ganesan Jeyasangar, Robert Jones, Mahaz Kayani, Ruth E Langley, Zafar Malik, Malcolm D Mason, David Matheson, Connor McAlpine, Archie Macnair, Robin Millman, Claire Murphy, Minal Padden-Modi, Omi Parikh, Chris Parker, Hannah Rush, Martin Russell, Rajaguru Srinivasan, Santhanam Sundar, Jacob S Tanguay, Fabio Turco, Patrick Williams, Matthew R Sydes, Mahesh K B Parmar, Louise C Brown, Noel W Clarke
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