Intricate relationship between aging and cancer – The Babak Lab
The Babak Lab shared a post on LinkedIn:
“Scientific Wednesdays: How Time Shapes Disease.
Exciting insights from Nature Aging summarize the intricate relationship between aging and cancer. This review explores how shared molecular pathways, such as genomic instability, telomere dysfunction, cellular senescence, and immune decline, drive both aging and tumorigenesis.
Key Takeaways:
- DNA Damage & Mutations: Accumulation over time fuels both aging and cancer, with clonal expansion of mutated cells playing a dual role.
- Telomeres: Short or damaged telomeres limit cell proliferation (anti-cancer) but can also promote genomic instability (pro-cancer).
- Senescence: While it halts precancerous cells, the senescence-associated secretory phenotype (SASP) can create a pro-inflammatory, tumor-permissive microenvironment.
- Immunosenescence: Aged immune systems struggle to clear senescent or malignant cells, exacerbating cancer risk.
Understanding these links opens doors for therapies targeting aging pathways to prevent or treat cancer. However, it is also important for preclinical models to better mimic aged microenvironments to improve translation.
Full article link can be found in comments section.
Click here for image source.”
“Important review on the mechanistic links between aging and cancer, covering DNA damage, telomere biology, and immunosenescence. Relevant for both basic and translational research.
Have a read!”
More posts featuring The Babak Lab.
-
Challenging the Status Quo in Colorectal Cancer 2024
December 6-8, 2024
-
ESMO 2024 Congress
September 13-17, 2024
-
ASCO Annual Meeting
May 30 - June 4, 2024
-
Yvonne Award 2024
May 31, 2024
-
OncoThon 2024, Online
Feb. 15, 2024
-
Global Summit on War & Cancer 2023, Online
Dec. 14-16, 2023