Jemma Arakelyan: Transition metal complexes as an approach for targeting emerging cancer hallmarks
Jemma Arakelyan, Medical Oncologist, CEO at the Institute of Cancer and Crisis, shared a post by
“There are over 100 types of cancer, but what unites them are the specific hallmarks proposed by Robert Weinberg and Douglas Hanahan. I had the privilege of meeting them at Harvard Medical School and attending their lecture on hallmarks firsthand.
With advancements in science, new hallmarks continue to emerge, and their papers remain among the most cited in the history of Cell. One of the first reviews we wrote when I began my PhD journey in The Babak Lab explored the interaction of metal-based drugs with cancer hallmarks.
I encourage you to take a look!”
“ScientificWednesday
Transition metal complexes as an approach for targeting emerging cancer hallmarks
Over the past decade, our understanding of cancer’s complexity has deepened significantly. Research has unveiled how cancer cells acquire specific hallmarks to transform into malignant cells. For today’s Scientific Wednesday post, we would like to invite our readers to have a read of our review, published in 2022. This article sheds light on innovative strategies for targeting cancer stem cells (CSCs) and the tumor microbiome using transition metal complexes.
Key takeaways:
• Phenotypic plasticity drives cancer cell invasion and metastasis.
• Epigenetic reprogramming regulates nonmutational changes influencing cell states.
• Transition metals are pivotal in the tumor microenvironment (TME), impacting cancer progression and treatment response.
• Microbiome interactions with transition metals unveil potential for innovative therapies.
To find out more about which transition metal complexes were found to deplete cancer stem cells (CSCs), access the article using the following link.”
Authors: Meng Rui Chang, Daniil A. Rusanov, Jemma Arakelyan, Mana Alshehri, Aleksandra V. Asaturova, Galina S. Kireeva, Maria V. Babak, Wee Han Ang.
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