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Genomic Stability Thresholds and DPY30 as a Biomarker in Pancreatic Cancer

Pancreatic cancer/X

Oct 27, 2024, 14:10

Genomic Stability Thresholds and DPY30 as a Biomarker in Pancreatic Cancer

Anirban Maitra, Professor of Pathology and Translational Molecular Pathology at UT MD Anderson Cancer Center, shared on X:

”New preprint from the MD Anderson Cancer Center Pancreatic Cancer team of famous Italians (Giulio Draetta, Giannicola Genovese, Mauro Di Pilato, Francesca Citron and Andrea Viale):

WRAD core perturbation impairs DNA replication fidelity promoting immunoediting in pancreatic cancer

Authors: Francesca Citron, I-Lin Ho, Chiara Balestrieri, Zhaoliang Liu, Er-Yen Nick Yen, Luca Cecchetto, Luigi Perelli, Li Zhang, Luis Alejandro Castillo Montanez, Nicholas Blazanin, Charles Alex Dyke, Rutvi Shah, Sergio Attanasio, Sanjana Srinivasan, Ko-Chien Chen, Ziheng Chen, Iolanda Scognamiglio, Nhung Pham, Hania Khan, Shan Jiang, Jing Pan, Benjamin Vanderkruk, Cecilia Leung, Mahinur Mattohti, Kunal Rai, Yanshuo Chu, Linghua Wang, Sisi Gao, Angela K Deem, Alessandro Carugo, Huamin Wang, Wantong Yao, Giovanni Tonon, Yun Xiong, Philip L Lorenzi, Chiara Bonini, Anna Zal, Brad Hoffman, Virginia Giuliani, Tim Heffernan, Collene R Jeter, Yonathan Lissanu, Giannicola Genovese, Mauro Di Pilato, Andrea Viale, Giulio F Draetta.

Even cancer cells require a certain threshold of genetic stability, crossing which can render them vulnerable to elimination. This study identifies a potential biomarker of genomic stability in pancreatic cancers (DPY30), loss of which leads to chromosomal instability and T cell mediated clearance of cells with complex karyotypes.”

Dr. Anirban Maitra serves as Professor of Pathology and Translational Molecular Pathology at UT MD Anderson Cancer Center since August 2013, and directs the Sheikh Ahmed Pancreatic Cancer Research Center. He leads an NCI-funded laboratory dedicated to pancreatic cancer research, focusing on genetics and molecular pathology in human and mouse models. His research aims to advance early detection and interception strategies to enhance patient survival rates in pancreatic cancer.

Alessandro Carugo Andrea Viale Angela K. Deem Anirban Maitra Anna Zal Benjamin Vanderkruk Brad Hoffman Cecilia Leung Charles Alex Dyke Chiara Balestrieri Chiara Bonini Collene R Jeter Er-Yen Nick Yen Francesca Citron Giannicola Genovese Giovanni Tonon Giulio Draetta Giulio F. Draetta Hania Khan Huamin Wang I-Lin Ho Iolanda Scognamiglio Jing Pan Ko-Chien Chen Kunal Rai Li Zhang Linghua Wang Luca Cecchetto Luigi Perelli Luis Alejandro Castillo Montanez Mahinur Mattohti Mauro Di Pilato Nhung Pham Nicholas Blazanin Pancreatic Cancer Philip L Lorenzi Rutvi Shah Sanjana Srinivasan Sergio Attanasio Shan Jiang Sisi Gao Tim Heffernan Virginia Giuliani Wantong Yao Yanshuo Chu Yonathan Lissanu Yun Xiong Zhaoliang Liu Ziheng Chen

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