Maximilian Merz: A comeback of checkpoint inhibition in Multiple Myeloma

Maximilian Merz shared a post on LinkedIn:

“Please check my latest article in Nature Cancer on A comeback of checkpoint inhibition in Multiple Myeloma.

We all remember the disappointment of PD1 blockade in combination with IMiDs for newly diagnosed and relapsed/refractory Myeloma.

In their new article from Madhav Dhodapkar‘s group, Shambavi Richard, Alexander Lesokhin and Barry Paul report on the positive effects of TIGIT-LAG3 blockade in RRMM.

They describe long term remissions and distinct changes in the immune microenvironment upon combination of anti-LAG3 or anti-TIGIT antibodies in combination with pomalidomide.

In my commentary, I argued that this might pave the way for new studies with novel immune checkpoint inhibitors especially in the context of bispecific antibodies and CAR T-cells.

Who would not love to see PD1-LAG3-TIGIT blockade before apheresis to get T-cells ready for manufacturing or as early maintenance after infusion to keep them going?!?

So much more to come and interesting study. ”

A comeback for checkpoint inhibition in multiple myeloma

Author: Maximilian Merz.

Source: Maximilian Merz/LinkedIn