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Sarcoma 101 at Fellowship Bootcamp with Steve Bialick – Miami Hematology Oncology Program Director
Aug 25, 2025, 16:30

Sarcoma 101 at Fellowship Bootcamp with Steve Bialick – Miami Hematology Oncology Program Director

Miami Hematology Oncology Program Director shared a post on X:

“As a center of excellence for Sarcoma and a major referral center, we included a dedicated Sarcoma 101 session in our Fellowship Bootcamp, led by Steve Bialick (Sylvester Comprehensive Cancer Center).

Key highlights from this high-yield session:

Sarcoma 101 at Fellowship Bootcamp with Steve Bialick - Miami Hematology Oncology Program Director

Biology and Genetics:
  • Mesenchymal origin – bone, cartilage, muscle, fat, connective tissue.
  • Genetic syndromes: Li-Fraumeni (TP53), Retinoblastoma (RB1), NF1/NF2, FAP (APC), Carney-Stratakis (KIT/PDGFRA).
  • Molecular drivers: KIT, PDGFR, RAF, MDM2, EWS-FLI1, SS18-SSX, INI1 loss.

Sarcoma 101 at Fellowship Bootcamp with Steve Bialick - Miami Hematology Oncology Program Director

Treatment Evolution:
  • Backbone chemo: Doxorubicin ± Ifosfamide.
  • Subtype-specific: Gem/Docetaxel (LMS), Vincristine/Irinotecan (Ewing’s), Paclitaxel (Angiosarcoma).
  • New FDA approvals since 2020: Nirogacestat, Atezolizumab, nab-Sirolimus, Crizotinib, Tazemetostat, Avapritinib, Ripretinib.
  • Precision is key: Molecular profiling is essential – just say YES to NGS!”

Sarcoma 101 at Fellowship Bootcamp with Steve Bialick - Miami Hematology Oncology Program Director

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