Zainab Hussain, Postdoctoral Researcher at Memorial Sloan Kettering Cancer Center, shared a post by Richard Tomasini, Research Director at INSERM (National Institute of Health and Medical Research), on LinkedIn, adding:
“Thrilled to share that our work on tumor cell-derived EVs in pancreatic cancer has been published in JCI! This study represents the major part of my PhD thesis work at CRCM – Centre de Recherche en Cancérologie de Marseille, and I’m incredibly proud to see it out in the world.
A huge thank you to my thesis director Richard Tomasini for his mentorship and support throughout, and to the entire team for their invaluable contributions. This was a true team effort, and I’m so grateful to everyone who helped bring it to completion. ”
Quoting Richard Tomasini’s post:
“Always a pleasure to announce our last study published in The Journal of Clinical Investigation, entitled ‘Tumor cell-derived extracellular vesicles foster the immunosuppressive landscape of pancreatic cancer’.
We must specifically acknowledge the great work done by Zainab Hussain, well supported by all the team members and especially Claudio Montenegro and Christopher Rovera.
Our findings highlight novel, dual mechanisms of TC-EVs-mediated crosstalk, involving ALOX15b+ Macrophages and SFRP1+ CAFs, that simultaneously contribute to foster the immunosuppressive ecosystem of pancreatic cancer.”
Title: Tumor cell-derived extracellular vesicles foster the immunosuppressive landscape of pancreatic cancer
Authors: Roger Stupp, Sophie Taillibert, Andrew Kanner, William Read, David Steinberg, Benoit Lhermitte, Steven Toms, Ahmed Idbaih, Manmeet S. Ahluwalia, Karen Fink, Francesco Di Meco, Frank Lieberman, Jay-Jiguang Zhu, Giuseppe Stragliotto, David Tran, Steven Brem, Andreas Hottinger, Eilon D. Kirson, Gitit Lavy-Shahaf, Uri Weinberg, Chae-Yong Kim, Sun-Ha Paek, Garth Nicholas, Jordi Bruna, Hal Hirte, Michael Weller, Yoram Palti, Monika E. Hegi, Zvi Ram
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