Yüksel Ürün, Medical Oncology Professor at Ankara University School of Medicine, shared a post on X:
“1. Obesity causes cancer. Not ‘might.’ Not ‘is linked to.’
10% of all new cancers in the US.
Up to 50% of endometrial and kidney cancers.
This is not a lifestyle conversation. It’s oncology.
2. Fat tissue doesn’t just sit there.
It inflames. It disrupts hormones. It feeds cancer cells directly, through tiny particles called extracellular vesicles. It also quiets the immune cells meant to stop tumors. Obesity reshapes the whole battlefield.
3. Over 1.6 million patients.
GLP-1 receptor agonists (semaglutide, tirzepatide) were associated with lower risk of 10 obesity-related cancers, including kidney, colorectal, and liver. Pancreatic cancer risk dropped by more than half.
We need randomized trials.
But the signal is real.
4. More than 10% weight loss may be needed to reduce cancer risk.
That’s not a number most lifestyle programs reach. As a GU oncologist, this matters to me. Kidney cancer is on this list.
What are we doing for our patients beyond the tumor?”
Title: Obesity and Cancer: A Translational Science Review
Authors: Sherry Shen, Kristy Brown, Angela Green, Neil Iyengar
Other articles featuring Yüksel Ürün on OncoDaily.