Yan Leyfman, Medical Oncologist, Co-Founder and Executive Director of MedNews Week, shared a post on LinkedIn:
”A promising step toward lung cancer interception.
Researchers identified a 14-protein plasma signature that predicts lung cancer risk more than 5 years before diagnosis, validated across 8 independent cohorts. The signature was linked to smoking, particulate matter exposure, IL-1β signaling, and early tumor-promoting cellular states in the lung.
Importantly, the biomarker also appeared to identify individuals most likely to benefit from IL-1β inhibition in the CANTOS study, potentially lowering the number needed to treat for lung cancer prevention.
Key implications:
- Blood-based risk stratification years before diagnosis
- Insights into inflammation-driven lung carcinogenesis
- Potential enrichment strategy for future prevention trials
- A step toward precision cancer prevention rather than population-wide intervention
Could circulating protein signatures help identify patients for targeted lung cancer prevention strategies before cancer develops?”
Title: Plasma signals of lung tumor promotion for molecular cancer prevention
Authors: Tej Pandya, Maria Zagorulya, Michelle M. Leung, Marcellus Augustine, Lydia Y. Liu, Aino-Maija Leppä, Ulysse Baruchel, Sin Wi Ng, Tamara Klockner, Miriam Mugabo, Anthony J. Griffen, Oleg Blyuss, Chrysante S. Iliakis, Amalie Grenov, Kerstin Haase, David C. Muller, Ka Hung Chan, Jincheng Wu, Vernon A. Burk, Neil Wright, Alix Le Marois, Ekaterina Pazukhina, Sophia Ward, Hubert Slawinski, Marc Pelletier, Cian Murphy, Matthew D. Park, Thomas Snoeks, Alejandro Suarez-Bonnet, Simon L. Priestnall, Alexandros Hardas, Charlotte Grieco, Ami Archer, Alpkaan Celik, Alejandro Jimenez-Sanchez, Rachel Scott, Hana Zahed, Léa Montégut, Rafael Meza, Clinton H. Durney, Stephen Lam, Takahiro Karasaki, Roel C. H. Vermeulen, Huilei Xu, Pablo Serrano-Fernandez, Tatjana Crnogorac-Jurcevic, Usha Menon, Sophia Apostolidou, Alexey Zaikin, Richard Gunu, Harry J. Whitwell, Zhe Huang, Zonglun Li, Xin Hu, Bo Zhu, Liming Li, María-Dolores Chirlaque, Marcela Guevara, P. Martijn Kolijn, Aghiles Guenoun, Neeloffer Mookherjee, Mattias Johansson, Ziqiao Wang, Nilanjan Chatterjee, Chao-Hua Chiu, Zhengming Chen, Dana Pe’er, Erik Sahai, Saskia Freytag, Andreas Wack, Marc J. Gunter, Miriam Merad, Jianjun Zhang, Christopher Carlsten, Pan-Chyr Yang, Hsuan-Yu Chen, Elizabeth A. Platz, Lindsay M. LaFave, Karl Smith-Byrne, Mariam Jamal-Hanjani, Kevin Litchfield, Nuno R. Nene, Nicholas McGranahan, Eva Grönroos, William Hill, Clare E. Weeden, Charles Swanton
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