Yan Leyfman, Medical Oncologist, Co-Founder and Executive Director of MedNews Week, shared a post on LinkedIn:
“Pioneering work led by Dr. Zihai Li, MD, PhD and the team at The Ohio State University College of Medicine uncovers a new hallmark of T cell exhaustion – the proteotoxic stress response (Tex-PSR).
- Tex-PSR is marked by increased protein translation, protein aggregation, and stress responses that drive T cell dysfunction in chronic infections and cancer.
- Targeting these proteostasis pathways improved cancer immunotherapy responses in preclinical models.
- High Tex-PSR levels in patient T cells were linked to poor clinical outcomes.
This discovery opens the door to new strategies for overcoming T cell exhaustion and boosting the effectiveness of immunotherapies.”
Title: Proteotoxic stress response drives T cell exhaustion and immune evasion
Authors: Yi Wang, Anjun Ma, No-Joon Song, Ariana Shannon, Yaa Amankwah, Xingyu Chen, Weidong Wu, Ziyu Wang, Abbey Saadey, Amir Yousif, Gautam Ghosh, Jay Mandula, Maria Velegraki, Tong Xiao, Haitao Wen, Stanley Huang, Ruoning Wang, Christian Beusch, Abdelhameed Dawood, David Gordon, Mohamed Abdel-Hakeem, Hazem Ghoneim, Gang Xin, Brian Searle, Zihai Li
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