Xiuning Le, Deputy Section Chief of Thoracic Medical Oncology at MD Anderson Cancer Center, shared a post on X:
“New online from our group at The University of Texas MD Anderson Cancer Center on ultra-precision oncology in lung cancer.
Analysis from over 22,000 EGFR-mutant tumor samples identified PACC mutations in 12% of cases (A).
While classical and Ex20 mutations more commonly occur as single mutations, PACC mutations are more frequently (66%) observed as compound mutations (B).
PACC/PACC and PACC/classical-like compound mutations function biologically similar to single PACC mutations, NOT classical mutations (C).
Compound PACC mutations demonstrate greater sensitivity to EGFR TKIs than single PACC mutations (D).”
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