Xiuning Le, Associate Professor, Deputy Section Chief of Thoracic Medical Oncology at MD Anderson Cancer Center, shared a post on LinkedIn about a recent article she and her colleagues co-authored, adding:
“The road map ahead for precision oncology
New online in Nature Reviews Clinical Oncology
‘Navigating the landscape in EGFR-mutant NSCLC — mechanisms and evolving treatment approaches’
Key themes shaping the next decade:
- Multi-omics beyond genomics — integrating epigenomics, transcriptomics, proteomics, and metabolomics to refine tumor biology.
- Adaptive treatment strategies — escalation and de-escalation guided by radiomics, ctDNA dynamics, and early response biomarkers.
- Personalized prediction — improving risk stratification, efficacy forecasting, toxicity modeling, and individualized treatment planning.
Global, multi-disciplinary collaboration remains essential as we work together to push precision oncology forward.”
Title: Navigating the landscape of EGFR TKI resistance in EGFR-mutant NSCLC — mechanisms and evolving treatment approaches
Authors: Jing Zhao, Wanting Xu, Fei Zhou, Xiangyu Zhang, Mo Zhou, Da Miao, Lan Yu, Yongchang Zhang, Junqiang Fan, Caicun Zhou, Wen Li, Tony Mok, Xiuning Le, Molly Li, Yang Xia
Read the Full Article on Nature Reviews Clinical Oncology

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