Walid Kamoun, Vice President, Global Head of R&D Oncology at Servier, shared a post on LinkedIn about a paper by Akshitkumar M Mistry et al. published in Neuro‑Oncology:
“Continuing my deep dive into neuro‑oncology, I wanted to highlight an impressive study recently published in Neuro‑Oncology (May 2025):
‘A clinically annotated transcriptomic atlas of nervous system tumors.’
Key takeaways:
This is likely the largest transcriptomic atlas of nervous system tumors (>5,400 samples), enabling robust comparative analyses across diagnoses.
It clearly demonstrates that transcriptomic signatures are highly distinct, mirroring the diagnostic power of DNA methylation.
The authors Identified six refined transcriptional subtypes of PH/PG, validated and linked to specific mutational and clinical features.
A big thank you to the authors — Chi H Le, Ajai K Nelson, Adam J Berrones, Janki R Naidugari, Robert P Naftel, Eyas M Hattab, Brian J Williams, Akshitkumar M Mistry — for this outstanding contribution to the field and for advancing science in such a meaningful way, creating a powerful resource that will likely boost our efforts to develop transformative therapies for brain tumor patients.”
Title: A clinically annotated transcriptomic atlas of nervous system tumors.
Authors: Chi H Le, Ajai K Nelson, Adam J Berrones, Janki R Naidugari, Robert P Naftel, Eyas M Hattab, Brian J Williams, and Akshitkumar M Mistry.
You can read the full article in Neuro‑Oncology.
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