Walid Kamoun, Vice President of Global Head of R&D Oncology at Servier, shared a post on LinkedIn about a paper by Melanie Clements et al. published in Nature:
“Another very interesting paper on GBM, highlighting the interaction between the tumor and the brain.
A recent study by Clements et al. (Nature, Oct 2025) reveals that axonal injury isn’t just a consequence of glioblastoma—it’s a driver of its progression.
The research shows that damage to white matter creates a microenvironment that accelerates tumor growth and invasion.
This discovery opens the door to targeting neuronal injury pathways as a novel therapeutic strategy for GBM.
Title: Axonal injury is a targetable driver of glioblastoma progression
Authors: Melanie Clements, Wenhao Tang, Zan Florjanic Baronik, Holly Simpson Ragdale, Roger Oria, Dimitrios Volteras, Ian J. White, Gordon Beattie, Imran Uddin, Tchern Lenn, Rachel Lindsay, Sara Castro Devesa, Saketh R. Karamched, Mark F. Lythgoe, Vahid Shahrezaei, Valerie M. Weaver, Ryoichi Sugisawa, Federico Roncaroli, Samuel Marguerat, Ciaran S. Hill, Simona Parrinello
You can read the Full Article in Nature.
More posts featuring Walid Kamoun.