Vivek Subbiah, Chief of Early-Phase Drug Development at the Sarah Cannon Research Institute, shared a post on LinkedIn:
“Just reading this stunning paper in Nature Journal on the ‘Spatial distribution of the proteome in the human body and across cancers‘
The implications are profound – understanding ‘where‘ proteins are expressed in healthy vs. malignant tissue opens entirely new doors for:
- Precision drug target identification.
- Drug repurposing with tissue-specific relevance.
- Better prediction of on-target/off-target effects.
Worth a deep read if you work in drug development, oncology, or biomarker discovery.”
Title: Spatial distribution of the proteome in the human body and in cancers
Authors: Liang Yue, Wenhao Jiang, Sainan Li, Meng Luo, Ning Fan, Xiaolu Zhan, Rui Sun, Honghan Cheng, Zhangzhi Xue, Tong Liu, Qianhe Zhou, Kexin Chen, Tian Lu, Fang Guo, Dongwei Li, Weigang Ge, Zongxiang Nie, Mengge Lyu, Jun A, Yingrui Wang, Yingdan Chen, Zhenhai Fu, Nan Xiang, Lu Li, Fengchao Yu, Guo Ci Teo, Alexey I. Nesvizhskii, Meng Wang, Michael P. Snyder, Ben C. Collins, Qi Xiao, Ruedi Aebersold, Fei Xu, Hui Yang, Sijia Zhang, Yi Han, Yi Zhu, Yong Ji, Yan Li, Tiannan Guo
Read The Full Article
Other articles about Precision Oncology on OncoDaily.