Vijay Tiwari, Professor at the Wellcome-Wolfson Institute for Experimental Medicine at Queen’s University, shared a post on LinkedIn about a recent article he and colleagues authored:
“A groundbreaking study from the lab of Prof. Ekin Demir, our esteemed Adjunct Professor, published in Cancer Cell, reveals a fascinating connection between sensory neurons and pancreatic cancer progression.
The research demonstrates that pancreatic cancer cells form pseudo-synapses with sensory neurons, using glutamate signaling to fuel their growth. By disrupting this glutamate-GRIN2D signaling pathway, the team significantly improved survival in cancer models.
This discovery, to which we had the pleasure of contributing, opens new doors for cancer-neuroscience-based therapies.”
Title: Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses
Authors: Lei Ren, Chunfeng Liu, Kaan Çifcibaşı, Markus Ballmann, Gerhard Rammes, Carmen Mota Reyes, Sergey Tokalov, Andreas Klingl, Jennifer Grünert, Keshav Goyal, Peter H. Neckel, Ulrich Mattheus, Benjamin Schoeps, Saliha Elif Yıldızhan, Osman Ugur Sezerman, Nedim Can Cevik, Elif Arik Sever, Didem Karakas, Okan Safak, Katja Steiger, Alexander Muckenhuber, Kıvanç Görgülü, Zongyao Chen, JingCheng Zhang, Linhan Ye, Mohammed Inayatullah Maula Ali, Vijay K. Tiwari, Nataliya Romanyuk, Florian Giesert, Dieter Saur, Roland Rad, Roland M. Schmid, Hana Algül, Achim Krüger, Helmut Friess, Güralp O. Ceyhan, Rouzanna Istvanffy, Ihsan Ekin Demir
Read the Full Article in Cancer Cell.
More posts featuring Pancreatic Cancer on OncoDaily.