Tom Lüdde, Director of the Department of Gastroenterology, Hepatology, and Infectious Diseases at University Hospital Düsseldorf, shared a post on LinkedIn about a recent article he and his colleagues co-authored, adding:
“Happy to share our new review in Nature Reviews Gastroenterology and Hepatology on ‘Regulated necrosis at the crossroads of liver inflammation and cancer development.”
In this article, we summarize how necroptosis, pyroptosis and ferroptosis contribute to inflammatory liver diseases and hepatocellular carcinoma, highlight open controversies about their roles in hepatocytes vs non-parenchymal cells, and discuss emerging therapeutic strategies targeting these death pathways to prevent disease progression or enhance anti-tumour immune responses.
We also outline key methodological advances and outstanding questions that need to be addressed to translate findings from preclinical models into clinical practice.”
Title: Regulated necrosis at the crossroads of liver inflammation and cancer development
Authors: Mihael Vucur, Vangelis Kondylis, Petr Broz, Tom Luedde
Read the Full Article on Nature Reviews Gastroenterology and Hepatology
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