Thor Halfdanarson, Professor of Oncology at Mayo Clinic School of Medicine, shared a post on X about a recent article he and his colleagues co-authored, adding:
“When does an elevated VIP level in a patient with diarrhea mean that patient has VIPoma…? Actually, not that often. Among 76 patients, 9 had VIPoma, and 5 of them a known diagnosis of panc NET. Using the threshold of 75 pg/mL (upper end of normal), the positive predictive value for a VIPoma was 12%. The optimal VIP threshold was 442 pg/mL with statistically significant odds ratios starting at 200 pg/mL.
So bottom line is that most patients wit diarrhea and elevated VIP levels do NOT have VIPoma. What then to they have… Well, that’s another project…
Excellent work led by Jack Korleski, a 1st year heme/onc fellow. Keep an eye on him, he’s good!”
Title: Elevated Vasoactive Intestinal Peptide Concentrations Poorly Predict VIPoma
Authors: Jack Korleski, Luis E. Ospina Velasquez, Joshua Bornhorst, Alicia Algeciras-Schimnich, Karl Ness, Timothy J. Hobday, Rachel Eiring, Patrick W. McGarrah, Jason Starr, Mohamad Bassam Sonbol, Johannes Hofland, Randall Pearson, Thorvardur R. Halfdanarson
Read the Full Article on Endocrine-Related Cancer
More posts featuring Thor Halfdanarson.