The Immunobuddies Podcast shared a post on X:
“Episode 181 is live!
RS3PE – A Wi-Fi password from the 90’s… or an actual toxicity?
Before you try typing it into your old PC, RS3PE is actually Remitting Seronegative Symmetrical Synovitis with Pitting Edema – a rare inflammatory rheumatological condition causing sudden symmetrical joint inflammation and puffy, pitting hands/feet, and yes… it can show up as an immune-related toxicity.
In this episode, we unpack:
- What RS3PE really is
- Why it’s being seen with immunotherapy
- How to recognise it (and not just blame bad Wi-Fi)
Listen now and find out why this “password” definitely shouldn’t be ignored.”

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