Why Hasn’t Immunotherapy Consistently Delivered in HER2+ Disease? – The Breast Friends
Jason Mouabbi and Paolo Tarantino

Why Hasn’t Immunotherapy Consistently Delivered in HER2+ Disease? – The Breast Friends

The Breast Friends Podcast shared a post on LinkedIn:

“Why hasn’t immunotherapy consistently delivered in HER2+ disease?
Dr. Paolo Tarantino and Dr. Jason A. Mouabbi discuss a major clinical paradox: HER2 antibodies already “flag” the immune system through ADCC, yet adding formal immunotherapy hasn’t moved the needle. It raises a fascinating question about whether “oncogene-driven” diseases are simply too “clean” for IO to thrive.

We’re watching 2026 data closely for a potential breakthrough.

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The Breast Friends

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