Talha Badar: 41 Yrs Old With AML Required Re-Induction Due to Residual Disease at D14

Talha Badar, Hematology/Oncology Specialist at Mayo Clinic, shared a post on X:

“41 yrs old with AML required re-induction due to residual disease at D14. Culture proven invasive aspergillosis refractory to Posaconazole.

How to manage:

1. Reassess diagnosis: check drug levels, Asp resistance mutation TR34/L98H (susceptibility testing), r/o co-mutations mucorales/bacterial.
2. Switch to Liposomal Amphotericin B, Dose: 5-10 mg/kg IV once daily.
3. If refractory to AmB, Isavuconazole.
4. Combination therapy in selected cases
5. Surgical consult for debridement.”

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