Stephen V Liu, Director of Thoracic Oncology, Chief of the Division of Hematology and Oncology, and Associate Professor at Georgetown Lombardi Comprehensive Cancer Center, shared a post on shared a post on X:
“Still learning about resistance to KRAS inhibitors.
Case report JTO and JTO CRR describes patients with KRAS G12C adenocarcinoma who responded to sotorasib but at resistance, biopsy showed ERBB3 amplification and pleomorphic histology. Highlights value of rebiopsy.”
Title: Lung Adenocarcinoma Developing Pleomorphic Carcinoma with ERBB3 Amplification After Acquired Resistance to Sotorasib: A Case Report
Authors: Satoru Senoo, Kohei Takata, Shunsuke Matsumori, Takahiro Baba, Yuka Sugisaki, Hiroki Omori, Hiroaki Matsuura, Yumi Matsuura, Rika Omote, Eiki Ichihara, Toshiaki Okada
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