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Siddhartha Yadav։ Precise Contralateral Breast Cancer Risk Estimates Based on CARRIERS and BRIDGES Data
Siddhartha Yadav/LinkedIn

Siddhartha Yadav։ Precise Contralateral Breast Cancer Risk Estimates Based on CARRIERS and BRIDGES Data

Siddhartha Yadav, Associate Professor of Oncology and Consultant Medical Oncologist at the Mayo Clinic, shared a post on X:

“Our combined analysis of the large CARRIERS and BRIDGES datasets provides more precise estimates of contralateral breast cancer risk among breast cancer survivors carrying germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2.

Take-home message: Breast cancer survivors carrying BRCA1, BRCA2, or CHEK2 PVs, as well as ER-negative survivors carrying PALB2 PVs, have at least a twofold increased risk of contralateral breast cancer. In contrast, ATM PV carriers do not have an elevated risk compared to non-carriers.”

Title: Contralateral breast cancer risks for BRCA1, BRCA2, PALB2, CHEK2, and ATM pathogenic variant carriers in two large cohort studies

Authors: Isaac Allen, Nancy Whish, Siddhartha Yadav, Nicholas Boddicker, Caroline Drukker, Irma van de Beek, Diana Eccles, Clare Turnbull, Paul Pharoah, Antonis Antoniou, Douglas Easton, Fergus Couch, Marjanka Schmidt, Marc Tischkowitz
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Siddhartha Yadav։ Precise Contralateral Breast Cancer Risk Estimates Based on CARRIERS and BRIDGES Data

Other articles featuring Siddhartha Yadav on OncoDaily..

Antonis Antoniou cancer Caroline Drukker Clare Turnbull Diana Eccles Douglas Easton Fergus Couch Irma van de Beek Isaac Allen Marc Tischkowitz Marjanka Schmidt Nancy Whish Nicholas Boddicker OncoDaily Oncology Paul Pharoah Siddhartha Yadav