Shrinidhi Nathany, Consultant Molecular Hematology and Oncology at Fortis Memorial Research Institute, India, shared a post on LinkedIn:
“Special mention to Dr. Neha Rastogi Panda Dr Zubin Dev Sharma, Siddharth Sagar, Abhishek Das – requesting discussion!
New Review Alert
The gut microbiome is no longer just a supportive care topic. It is rapidly becoming a key component of lymphoma biology and precision oncology.
A comprehensive 2026 Blood Reviews article by Vickers et al. brings together the evolving evidence on how the gut microbiome influences B-cell lymphoma, from disease development to treatment outcomes and future therapeutic strategies.
Key highlights
- The gut microbiome influences immune regulation and may contribute to lymphomagenesis.
- Distinct patterns of dysbiosis have been associated with disease characteristics and clinical outcomes in B-cell lymphomas.
- Microbial composition may affect response to chemoimmunotherapy and the risk of treatment-related toxicity.
- Antibiotic exposure can alter the microbiome and may influence outcomes, particularly in patients receiving intensive therapies.
- Emerging evidence links the microbiome with responses to cellular therapies, including CAR-T.
- Microbiome modulation through diet, probiotics, prebiotics or fecal microbiota transplantation remains investigational but represents an exciting area of translational research.
Why this matters in clinical practice
- Consider the microbiome as a potential biomarker alongside molecular and immune profiling.
- Judicious antibiotic stewardship may become increasingly important in lymphoma care.
- Future risk stratification models may integrate microbiome signatures with genomic and clinical biomarkers.
- Understanding microbiome-host interactions could help personalize supportive care and improve treatment outcomes.
- Prospective clinical trials are now needed to validate microbiome-guided interventions before routine clinical adoption.
The future of precision hematology may not depend only on the lymphoma genome, but also on the microbial ecosystem that coexists with it.
Reference:
Vickers D, Martynchyk A, Henden A, Smibert OC, Hawkes EA, Chong G. The gut microbiome in B cell lymphoma. Blood Reviews. 2026;76:101357.”
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