Shree Rath, GBD Collaborator, shared a post on LinkedIn:
“Pleased to share our latest publication in Urologic Oncology exploring the tumor-microbiome-host transcriptome axis (oncobiome) in Non–Muscle Invasive Bladder Cancer.
Using paired tumor and adjacent normal bladder mucosa from the same patients, we applied shotgun meta-transcriptomics to uncover early biological signals that may shape recurrence and progression.
Our key findings include:
- 57 differentially expressed host genes, predominantly involved in extracellular matrix remodeling and structural integrity
- Significantly reduced microbial species richness in tumor tissue compared with adjacent normal mucosa (P = 0.026)
- Propionibacterium acnes enriched in tumor sites (by 24%), suggesting a potential pro-tumorigenic role
- Bifidobacterium longum enriched in normal mucosa, correlating with genes involved in extracellular homeostasis, supporting a possible protective role
- 80 significant host–microbe correlations, highlighting matrix-regulating genes (TMEM119, FBN2, MGP) as central interaction hubs.
This study provides early evidence that microbial dysbiosis and extracellular matrix disruption are tightly linked in NMIBC, opening doors for microbiome-informed risk stratification and future microbiome-targeted interventions.
Grateful to my co-authors and mentors for this collaborative effort.”
Title: Microbiome-linked transcriptomic signatures in NMIBC: Toward personalized urologic-oncology
Authors: Manoj Das, Shree Rath, Rohith Gorepatti, Rishikesh Dash, Abhishek Akella, Abhay Singh Gaur, Giriprasad Venugopal, Zaiba Hasan Khan, Balamurugan Ramadass, Prasant Nayak
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