Sergio Cifuentes, Medical Oncologist at Las Américas Auna Clinic, shared a post on X:
“Implementing SERENA6 in the clinic in the UAE: critical thinking of a community oncologist.
Key editorial for LMICS
One key challenge after SERENA-6: Can we realistically implement this in real-world community oncology?”
ctDNA monitoring with Guardant360 every 2–3 months is costly and difficult to scale globally. We urgently need smarter strategies—when, how often, and for whom to test.
- Highest ESR1m detection occurs between 6–30 months on AI + CDK4/6i (PADA-1)
- SERENA-6 shows median ESR1m detection at 22 months, after ≥6 months on therapy.
Testing more frequently in this interval—and less after 30 months—may be reasonable.”
Title: Implementing SERENA6 in the clinic in the UAE: critical thinking of a community oncologist
Author: S. Dawood
Read the Full Article on ESMO Open

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