Sendurai Mani, Associate Director of Translational Oncology, Dean’s Chair of Translational Oncology, and Professor of Medicine at Brown University, and Co-Founder and CSO of Iylon Precision Oncology, shared a post on LinkedIn about a paper he co-authored with colleagues published in iScience:
“This video, generated by NotebookLM, summarizes key findings from our work (Den Hollander et al., iScience, 2025) on EMT, stemness, and cellular heterogeneity.
It shows that although EMT broadly induces mesenchymal traits, only a subset of cells acquires stem-like properties, highlighting the underlying molecular mechanisms and their implications for cancer progression and therapy.”
Proceed to watch the video attached to the post.
Title: EMT-induced stem cell and mesenchymal programs can be decoupled via cell division and ESRP1-dependent mechanisms
Authors: Petra den Hollander, Maria Castaneda, Suhas V. Vasaikar, Joanna Joyce Maddela, Claire Gould, Breanna R. Demestichas, Robiya Joseph, Shivangi Agarwal, Abhijeet P. Deshmukh, Alvina Zia, Shruti Shah, Tieling Zhou, Geraldine Raja, Paul Allegakoen, Nick A. Kuburich, Mika Pietila, Chunxiao Fu, Jeffrey Chang, Chad J. Creighton, William F. Symmans, Rama Soundararajan, Sendurai A. Mani
You can read the full article in iScience Cell Press.
More posts featuring Sendurai Mani.